<kbd id="h0baltrk"></kbd><address id="h0baltrk"><style id="h0baltrk"></style></address><button id="h0baltrk"></button>

              <kbd id="m0rhjei3"></kbd><address id="m0rhjei3"><style id="m0rhjei3"></style></address><button id="m0rhjei3"></button>

                      <kbd id="pfri4o80"></kbd><address id="pfri4o80"><style id="pfri4o80"></style></address><button id="pfri4o80"></button>

                              <kbd id="1w3k78m2"></kbd><address id="1w3k78m2"><style id="1w3k78m2"></style></address><button id="1w3k78m2"></button>

                                      <kbd id="chxuw988"></kbd><address id="chxuw988"><style id="chxuw988"></style></address><button id="chxuw988"></button>

                                              <kbd id="jtaazci5"></kbd><address id="jtaazci5"><style id="jtaazci5"></style></address><button id="jtaazci5"></button>

                                                      <kbd id="rmoqveg7"></kbd><address id="rmoqveg7"><style id="rmoqveg7"></style></address><button id="rmoqveg7"></button>

                                                              <kbd id="mujb9q90"></kbd><address id="mujb9q90"><style id="mujb9q90"></style></address><button id="mujb9q90"></button>

                                                                  澳门葡京游戏
                                                                  登录 | 中文版 | English
                                                                  中心成员
                                                                  PI 首页> 中心成员 > PI
                                                                    PI
                                                                    副研究员
                                                                    行政人员

                                                                  陈 兴

                                                                   

                                                                  特聘研究员 ,博士生导师

                                                                  电子信箱:xingchen#pku.edu.cn

                                                                  课题组网站  http://www.grayhatworLd.com/xchengrp/

                                                                   

                                                                  教育和研究背景


                                                                  2002年 本科毕业于清华大学化学系。
                                                                  2007年 获得加州大学伯克利分校化学博士学位 ,研究领域为化学生物学和纳米生物技术  。
                                                                  2007-2010年,在哈佛大学医澳门葡京游戏平台从事博士后研究,研究领域为结构生物学和免疫生物学。
                                                                  2010年9月- 至今,任澳门葡京平台化学生物学系 特聘研究员
                                                                  。


                                                                  研究领域与兴趣


                                                                  本课题组的研究兴趣集中于有机化学、纳米化学、糖生物学、细胞生物学的交叉领域。我们综合应用化学方法、生物手段和纳米技术,研究生命科学中的重要问题。
                                                                  1.化学糖生物学(Chemical Glycobiology)
                                                                  2.生物纳米技术

                                                                  课题组网址www.grayhatworLd.com/xchengrp 

                                                                   

                                                                  发表论文


                                                                  ……………………………………………….2014

                                                                  Xiao, M.; Lin, L.; Li, Z.; Liu, J.; Hong, S.; Li, Y.; Zheng, M.; Duan, X.; Chen, X. “SERS Imaging of Cell-Surface Biomolecules Metabolically Labeled With Bioorthogonal Raman Reporters”
                                                                  Chem. Asian J. 2014, DOI: 10.1002/asia.201402151.

                                                                  Hong, S.; Chen, T.; Zhu, Y.; Li, A.; Huang, Y.; Chen, X. “
                                                                  Live-Cell Stimulated Raman Scattering Imaging of Alkyne-Tagged Biomolecules” Angew. Chem. Int. Ed. 2014, DOI: 10.1002/anie.201400328.

                                                                  Lin, W.; Du, Y.; Zhu, Y.; Chen, X.
                                                                  “A Cis-membrane FRET-based Method for Protein-Specific Imaging of Cell-surface Glycans” J. Am. Chem. Soc. 2014,136, 679-687.

                                                                  ……………………………………………….2013

                                                                  Li, S.; Zhang, L.; Yao, Q.; Li L.; Dong, N.; Rong, J.; Gao, W.; Ding, X.; Sun, L.; Chen, X.; Chen, S.; Shao, F.
                                                                  “Pathogen Blocks Host Death Receptor Signalling by Arginine GlcNAcylation of Death Domains” Nature 2013, 501, 242-246.

                                                                  Xie, R.; Hong, S.; Chen, X.
                                                                  “Cell-selective Metabolic Labeling of Biomolecules with Bioorthogonal Functionalities” Curr. Opin. Chem. Biol. 2013, 17, 747-752.

                                                                  Feng, L.; Hong, S.; Rong, J.; You, Q.; Dai, P.; Huang, R.; Tan, Y.; Hong, W.; Xie, C.; Zhao, J.; Chen, X.
                                                                  “Bifunctional Unnatural Sialic Acids for Dual Metabolic Labeling of Cell-Surface Sialylated Glycans” J. Am. Chem. Soc. 2013, 135, 9244-9247

                                                                  Lin, L.; Tian, X.; Hong, S.; Dai, P.; You, Q.; Wang, R.; Feng, L.; Xie, C.; Tian, Z.; Chen, X.
                                                                  “A Bioorthogonal Raman Reporter Strategy for SERS Detection of Glycans on Live Cells.” Angew. Chem. Int. Ed. 2013, 52, 7266-7271.

                                                                  Zhang, C.; Yin, A.; Jiang, R.; Rong, J.; Dong, L.; Zhao, T.; Sun, L.; Wang, J.; Chen, X.; Yan, C.; “
                                                                  Time-Temperature Indicator for Perishable Products Based on Kinetically Programmable Ag Overgrowth on Au NanorodsACS Nano 2013, 7, 4561-4568.

                                                                  ……………………………………………….2012

                                                                  Rouhanifard, S. H.; Xie, R.; Zhang, G.; Sun, X.; Chen, X.; Wu, P.
                                                                  “Detection and Isolation of Dendritic Cells Using Lewis X-Functionalized Magnetic Nanoparticles” Biomacromolecules 2012, 13, 3039-3045.

                                                                  Xie, R.; Hong, S.; Feng, L.; Rong, J.; Chen, X.
                                                                  “Cell-Selective Metabolic Glycan Labeling Based on Ligand-Targeted Liposomes” J. Am. Chem. Soc. 2012, 134, 9914-9917.

                                                                  ……………………………………………….2011

                                                                  Wang, W.; Hong, S.; Tran, A.; Triano, R.; Jiang, H.; Liu, Y; Chen, X.; Wu, P.
                                                                  “Sulfated Ligands for the Copper(I)-catalyzed Azide Alkyne Cycloaddition” Chem. Asian J. 2011, 6, 2796-2802.

                                                                  Hao, Z.; Hong, S.; Chen, X.; Chen, R. P.
                                                                  “Introducing Bioorthogonal Functionalities into Proteins in Living Cells Acc. Chem. Res. 2011, 44, 742-751.


                                                                  Prior to PKU:


                                                                  Chen, X.; Yu, Y.; Mi, L.; Walz, T.; Springer, T. A. “Molecular Basis for Complement Recognition by Integrin
                                                                  αXβ2Proc. Natl. Acad. Sci. USA 2012, 109, 4586-4591.

                                                                  Shi, M.; Zhu, J.; Wang, R.; Chen, X.; Mi, L.; Walz, T.; Springer, T. A. “Latent TGF-
                                                                  β Structure and Activation ” Nature 2011, 474, 343-349.

                                                                  Chen, X.; Xie, C.; Nishida, N.; Li, Z.; Walz, T.; Springer, T. A. “Requirement of Open Headpiece Conformation for Activation of Leukocyte Integrin
                                                                  αXβ2Proc. Natl. Acad. Sci. USA 2010, 107, 14727-14732.

                                                                  Xie, C; Zhu, J.; Chen, X.; Lizhi Mi; Nishida, N.; Springer, T. A. “Structure of Complement Receptor Tpye 4, An Integrin with An
                                                                  αI Domain” EMBO J. 2010, 29, 666-678.

                                                                  Chang, P.; Chen, X.; Smyrniotis, C.; Xenakis, A.; Hu, T; Bertozzi, C. R.; Wu, P.; “Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars”
                                                                  Angew. Chem. Int. Ed. 2009, 48, 4030-4033.

                                                                  Chen, X.; Wu, P.; Rousseas, M.; Okawa, D.; Gartner, Z.; Zettl, A.; Bertozzi, C. R. “Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells”
                                                                  J. Am. Chem. Soc. 2009, 131, 890-891.

                                                                  Wu, P.; Chen, X.; Hu, N.; Tam, U. C.; Blixt, O.; Zettl, A.; Bertozzi, C. R. “Biocompatible Carbon Nanotubes Generated by Functionalization with Glycodendrimers”
                                                                  Angew. Chem. Int. Ed. 2008, 47, 5022-5055.

                                                                  Chen, X.; Kis, A.; Zettl, A.; Bertozzi, C. R. “A Cell Nanoinjector Based on Carbon Nanotubes”
                                                                  Proc. Natl. Acad. Sci. USA 2007, 104, 8218-8222.

                                                                  Rabuka, D.; Parthasarathy, R.; Lee, G. S.; Chen, X.; Groves, J. T.; Bertozzi, C. R. “Hierarchical Assembly of Model Cell Surfaces: Synthesis of Mucin Mimetic Polymers and their Display on Supported Bilayers”
                                                                  J. Am. Chem. Soc. 2007, 129, 5462-5471.

                                                                  Chen, X.; Tam, U. C.; Czlapinski, J. L.; Lee G. S.; Rabuka, D.; Zettl, A.; Bertozzi, C. R. “Interfacing Carbon Nanotubes with Living Cells” J. Am. Chem. Soc. 2006, 128, 6292-6293.


                                                                  Chen, X.; Lee G. S.; Zettl A.; Bertozzi, C. R. “Biomimetic Engineering of Carbon Nanotubes Using Cell Surface Mucin Mimics”
                                                                  Angew. Chem. Int. Ed. 2004, 43, 6111-6116.

                                                                  Sun, X.; Chen, X.; Li, Y. “A CTAB-Assisted Hydrothermal Orientation Growth of ZnO Nanorods”
                                                                  Mater. Chem. Phys. 2003, 78, 99-104.

                                                                  Sun, X.; Chen, X.; Li, Y. “Large-Scale Synthesis of Sodium and Potassium Titanate”
                                                                  Inorg. Chem. 2002, 41, 4996-4998.

                                                                  Sun, X.; Chen, X.; Li, Y. “Evaporation Growth of Multipod ZnO Whisker Assisted by A Cu
                                                                  2+ Etching Technique” J. Crystal. Growth. 2002, 244, 218-223.

                                                                  Chen, X.; Sun, X.; Li, Y. “Self-Assembling Vanadium Oxide Nanotubes by Organic Molecular Templates”
                                                                  Inorg. Chem. 2002, 41, 4524-4530.

                                                                  Chen, X.; Deng, Z.; Li, Y.; Li, Y. “Hydrothermal Synthesis and Superparamagnetic Behaviors of A Series of Ferrite Nanoparticles”
                                                                  Chin. J. Inorg. Chem. 2002, 18, 460-464.

                                                                  中心概况 | 中心新闻 | 联系我们     版权所有©2013 澳门葡京游戏合成与功能生物分子中心