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                                          PI 首页> 中心成员 > PI

                                          何 川




                                          1995-2000 美国麻省理工澳门葡京游戏平台化学系 ,理学博士
                                          2000-2002 美国哈佛大学化学系,博士后
                                          2002-2008 美国芝加哥大学化学系,助理教授
                                          2008-2010 美国芝加哥大学化学系,副教授
                                          2009-至今 澳门葡京游戏,讲座教授
                                          2010-至今 芝加哥大学化学系 ,教授
                                          2011-至今 澳门葡京游戏合成与功能生物分子中心  ,主任
                                          2012-至今 芝加哥大学生物物理动态研究所 ,主任



                                          3.研究和证明多种临床感染性病原体中的全局性调控蛋白的调控机理 。
                                          5.金属蛋白调控机理研究与金属蛋白进化 。

                                                Our research program spans a broad range of chemical biology, nucleic acid chemistry and biology, epigenetics, cell biology, bioinorganic chemistry, structural biology, microbiology, and genomics. We probe the pathways and mechanisms of nucleic acids modification and demodification. We study virulence and antibiotic resistance regulation in human pathogens. We also study selective metal ion recognition and sensing by naturally occurring and engineered proteins, and live-cell imaging of metal ions and other small molecules such as H2S, heme, and CO.


                                          实验室网址: he-group.uchicago.edu/ 


                                          1. Yu, M.; Hon, G. C.; Szulwach, K. E.; Song, C.-X.; Zhang, L.; Kim, A.; Li, X.; Dai, Q.; Shen, Y.; Park, B.; Min, J.-H.; Jin, P.*; Ren, B.*; He, C.* Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome. Cell 2012, on-line.
                                          2. Yi, C.; Chen, B.; Zhang, W.; Jia, G.; Zhang, L.; Li, C. J.; Dinner, A. R.; Yang, C.-G.*; He, C.* Duplex Interrogation by a Direct DNA Repair Protein in Search of Base Damage. Nat. Struct. Mol. Biol. 2012, on-line.
                                          3. Zhang, L.; Lu, X.Y.; Lu, J.Y.; Liang, H.H.; Dai, Q.; Xu, G.L.; Luo, C.; Jiang, H.L.; He, C. Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat. Chem. Biol. 2012, 8, 328-330.
                                          4. Jia, G.; Fu, Y.; Zhao, X.; Dai, Q.; Zheng, G.; Yang, Y.; Yi, C.; Lindahl, T.; Yang, Y.-G.; He, C.* “N6-methyladesosine in nuclear RNA is a major substrate of the obesity-assoc
                                          5. Qian, Y.; Karpus, J.; Kabil, O.; Zhang, S.-Y.; Zhu, H.-L.; Banerjee, R.; Zhao, J.; He, C.* “Selective fluorescent probes for live-cell monitoring of sulfide” Nature Commun. 2011, 2, 495.
                                          6. He, Y.; Li, B.; Li, Z.; Liu, P.; Wang, Y.; Tang, Q.; Ding, J.; Jia, Y.; Chen, Z.; Li, L.; Sun, Y.; Li, X.; Dai, Q.; Song, C.-X.; Zhang, K.; He, C.; Xu, G.* “Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA” Science, 2011, 333, 1303-1307.
                                          7. Ito, S.; Shen, L.; Dai, Q.; Wu, S. C.; Collins, L. B.; Swenberg, J. A.; He, C.; Zhang, Y.* “Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine” Science, 2011, 333, 1300-1303.
                                          8. Song, C.-X.; Szulwach, K. E.; Fu, Y.; Dai, Q.; Yi, C.; Li, X.; Chen, C.-H.; Zhang, W.; Jian, X.; Wang, J.; Zhang, L.; Looney, T. J.; Zhang, B.; Godley, L. A.; Hicks, L. M.; Lahn, B. T.; Jin, P.*; He, C*. “Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine” Nature Biotechnol., 2011, 29, 68-72.
                                          9. Yi, C.; Jia, G; Hou, G.; Dai, Q.; Zhang, W.; Zheng, G.; Jian, X.; Yang, C.-G.; Cui, Q.; He, C.* “Iron-catalysed Oxidation Intermediates Captured in a DNA Repair Dioxygenase” Nature, 2010, 468, 330-333.
                                          10. Yang, C.-G.; Yi, C.; Duguid, E. M.; Sullivan, C. T.; Jian, X.; Rice, P. A.; He, C.* “Crystal Structures of DNA-RNA Repair Enzymes AlkB and ABH2 Bound to dsDNA” Nature, 2008, 452, 961-965.
                                          11. Chen, P.; Bae, T.; Williams, W. A.; Duguid, E. M.; Rice, P. A.; Schneewind, O.; He, C.* “An Oxidation Sensing Mechanism is Used by A Global Regulator of Staphylococcus aureus” Nature Chem. Biol. 2006, 2, 591-595.
                                          12. Chen, H.; Hu, J.; Chen, P. R.; Lan, L.; Li, Z.; Hicks, L. M.; Dinner, A. R.; He, C.* “The Pseudomonas aeruginosa Multidrug Efflux Regulator MexR Uses An Oxidation Sensing Mechanism” Proc. Natl. Acad. Sci. 2008, 105, 13586-13591.

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